Genomics of Reproduction
My current research in reproductive genomics focuses on comparative RNA biology. In mammals, up to 75% of genes use alternative promoters, isoforms or polyadenylation sites, contributing greatly to transcriptome flexibility, diversity and dynamics. We create state-of-the-art tools for profiling the full transcriptome that will advance the field of functional genomics and increase its applicability to solve unmet problems in human health and animal reproduction. We believe that accurate profiling of transcript variants will promote the discovery of genetic mutations that underlie complex phenotypes, aid in the selection of regulatory switch units for functional characterization, and discover alternative variants that can be used for disease diagnosis and drug discovery in humans and for biomarker selection in animals.
Research PublicationsBrutman JN, Zhou X, Zhang Y, Michal J, Stark B, Jiang Z, Davis JF. 2018. Mapping diet-induced alternative polyadenylation of hypothalamic transcripts in the obese rat. Physiol Behav. 188:173-180.
Zhou X, Michal JJ, Jiang Z, Liu B. 2017. MicroRNA expression profiling in alveolar macrophages of indigenous Chinese Tongcheng pigs infected with PRRSV in vivo. J Appl Genet. 58(4):539-544.
Zhou X, Li R, Michal JJ, Wu XL, Liu Z, Zhao H, Xia Y, Du W, Wildung MR, Pouchnik DJ, Harland RM, Jiang Z. 2016. Accurate profiling of gene expression and alternative polyadenylation with whole transcriptome termini site sequencing (WTTS-Seq). Genetics. 203(2): 683-697 (Issue Highlights).
El-Halawany N, Zhou X, Al-Tohamy A, El-Sayed Y, Shawky A, Michal JJ, Jiang Z. 2016. Genome-wide screening of candidate genes for improving fertility in Egyptian native Rahmani sheep. Anim Genet. 47(4):513.
Wei S, Du M, Jiang Z, Hausman GJ, Zhang L, Dodson MV. 2016. Long noncoding RNAs in regulating adipogenesis: new RNAs shed lights on obesity. Cell Mol Life Sci. 73(10):2079-2087.
Jiang Z, Wang H, Michal JJ, Zhou X, Solberg Woods LC, Fuchs RA. 2016. Genome wide sampling sequencing for SNP genotyping: methods, challenges and future development. Int J Biol Sci. 12(1): 100-108.
Sun W, Dodson MV, Jiang Z, Yu S, Chu W, Chen J. 2016. Myostatin inhibits porcine intramuscular preadipocyte differentiation in vitro. Domest Anim Endocrinol. 55:25-31.